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Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation.

Abstract:

Expression of the myeloid transcription factor GATA1 is required for early stages of eosinophil differentiation. Defining mechanisms regulating eosinophil GATA1 expression will be important to understand development of this lineage. However, the cis-elements required for eosinophil GATA1 expression are not fully characterized. Previous work identified HS 1 as a major GATA1 enhancer, but its role in eosinophil GATA1 expression is unclear. Here, we show that mouse HS 1 deletion leaves eosinophi...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2004-01-0108

Authors


Valverde-Garduno, V More by this author
Porcher, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Journal:
Blood
Volume:
104
Issue:
1
Pages:
89-91
Publication date:
2004-07-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3c9ab7a5-3eae-4016-a7ed-393fc75e959b
Source identifiers:
32655
Local pid:
pubs:32655

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