- Abstract:
-
Perforin-mediated cytotoxicity is an essential host defense, in which defects contribute to tumor development and pathogenic disorders including autoimmunity and autoinflammation. How perforin (PFN) facilitates intracellular delivery of pro-apoptotic and inflammatory granzymes across the bilayer of targets remains unresolved. Here we show that cellular susceptibility to granzyme B (GzmB) correlates with rapid PFN-induced phosphatidylserine externalization, suggesting that pores are formed at ...
Expand abstract - Publisher copy:
- 10.1038/cdd.2014.110
-
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- Journal:
- Cell death and differentiation
- Volume:
- 22
- Issue:
- 1
- Pages:
- 74-85
- Publication date:
- 2015-01-05
- DOI:
- EISSN:
-
1476-5403
- ISSN:
-
1350-9047
- URN:
-
uuid:3c894281-5c72-423f-a5f3-44c9be77f811
- Source identifiers:
-
482492
- Local pid:
- pubs:482492
- Language:
- English
- Copyright date:
- 2015
Journal article
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
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