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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

Abstract:

Perforin-mediated cytotoxicity is an essential host defense, in which defects contribute to tumor development and pathogenic disorders including autoimmunity and autoinflammation. How perforin (PFN) facilitates intracellular delivery of pro-apoptotic and inflammatory granzymes across the bilayer of targets remains unresolved. Here we show that cellular susceptibility to granzyme B (GzmB) correlates with rapid PFN-induced phosphatidylserine externalization, suggesting that pores are formed at ...

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Publisher copy:
10.1038/cdd.2014.110

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Journal:
Cell death and differentiation
Volume:
22
Issue:
1
Pages:
74-85
Publication date:
2015-01-05
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
URN:
uuid:3c894281-5c72-423f-a5f3-44c9be77f811
Source identifiers:
482492
Local pid:
pubs:482492
Language:
English

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