Regulatory T cells in transplantation tolerance.

Journal article

The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate..

Authors: Wood, K; Sakaguchi, S

• Publication status: Published
• Journal: Nature reviews. Immunology
• Volume: 3
• Issue: 3
• Pages: 199-210
• Publication date: 2003-03-01
• DOI: 10.1038/nri1027
• EISSN: 1474-1741
• ISSN: 1474-1733
• Language: English
• Keywords: T-Lymphocytes, Regulatory; Isoantigens; Antigens, CD4; Animals; Graft Rejection; Transplantation Tolerance; Transplantation Immunology; Receptors, Interleukin-2; Humans; Lymphocyte Subsets; Species Specificity