Journal article
Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
- Abstract:
-
Nicotinic acid adenine dinucleotide phosphate (NAADP, 1) is the most potent intracellular Ca2+ mobilizing agent in important mammalian cells and tissues, yet the identity of the NAADP receptor is elusive. Significantly, the coenzyme NADP is completely inactive in this respect. Current studies are restricted by the paucity of any chemical probes beyond NAADP itself, and importantly, none is cell permeant. We report simple nicotinic acid-derived pyridinium analogs as low molecular weight compou...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Chemistry and biology
- Volume:
- 13
- Issue:
- 6
- Pages:
- 659-665
- Publication date:
- 2006-06-01
- DOI:
- EISSN:
-
1879-1301
- ISSN:
-
1074-5521
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106464
- UUID:
-
uuid:3c4fac38-a5f0-4940-923d-45d7141e418a
- Local pid:
- pubs:106464
- Source identifiers:
-
106464
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2006
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