Journal article icon

Journal article

The oxidation of naphthalene and pyrene by cytochrome P450cam.

Abstract:

Mutants of the heme monooxygenase cytochrome P450cam in which Y96 had been replaced with hydrophobic residues, have been shown to oxidise naphthalene and pyrene with rates one to two orders of magnitude faster than the wild-type. Naphthalene was oxidised to 1- and 2-naphthol, probably via the 1,2-oxide intermediate. In the case of the Y96F mutant, naphthalene was oxidised at a rate comparable to camphor. Pyrene oxidation gave 1,6- and 1,8-pyrenequinone with no evidence for attack at the K-reg...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
Journal:
FEBS letters
Volume:
424
Issue:
3
Pages:
271-274
Publication date:
1998-03-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
36168
Language:
English
Keywords:
Pubs id:
pubs:36168
UUID:
uuid:3c477b85-cf1e-49b2-821a-5bc3b5ff4da1
Local pid:
pubs:36168
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP