Journal article
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension
- Abstract:
-
It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a novel approach to uncover significant gene-gene interactions in a systematic two-dimensional (2D) genome-scan of essential hypertension. The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the British Genetics of HyperTension study. Extensive simulations were used to estab...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Barts and London Charitable Foundation Research Advisory Board
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Funding agency for:
Wallace, C
Grant:
RAB03/PJ/01
+ "Natural Sciences and Engineering Research Council of Canada", "the Fonds quebecois de la recherche sur la nature et les technologies", "Clarendon Fund"
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Funding agency for:
Tzenova Bell, J
The UK Medical Research Council
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human Molecular Genetics Journal website
- Volume:
- 15
- Issue:
- 8
- Pages:
- 1365-1374
- Publication date:
- 2006-04-01
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:3c2b3fd4-4afb-4579-acc8-d9cbda9dc2b4
- Local pid:
- ora:1650
- Deposit date:
- 2008-03-14
Related Items
Terms of use
- Copyright holder:
- Jordana Tzenova Bell et al
- Copyright date:
- 2006
- Notes:
- Originally published as: Tzenova Bell, J. et al. (2006). 'Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension', Human Molecular Genetics, 15(8), 1365-1374. [Available at http://hmg.oxfordjournals.org/]. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: journals.permissions@oxfordjournals.org
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