Investigation of porous graphitic carbon at high-temperature liquid chromatography with evaporative light scattering detection for the analysis of the drug combination artesunate--azithromycin for the treatment of severe malaria.

Journal article

Artesunate combined therapies represent the best option for the treatment of malaria and require the development of new methods of analysis. Retention, selectivity and detection with high-temperature liquid chromatography-porous graphitic carbon-evaporative light scattering detection was studied for artesunate and azithromycin separation. Organic solvent, concentration of organic modifiers, temperature and flow rate were all relevant parameters to optimize this separation. The behaviour of ar...

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Authors: Gaudin, K; Millet, P; Fawaz, F; Olliaro, P; White, N

• Publication status: Published
• Journal: Journal of chromatography. A
• Volume: 1217
• Issue: 1
• Pages: 75-81
• Publication date: 2010-01-01
• DOI: 10.1016/j.chroma.2009.11.015
• EISSN: 1873-3778
• ISSN: 0021-9673
• Language: English
• Keywords: Chromatography, High Pressure Liquid; Porosity; Graphite; Antimalarials; Azithromycin; Artemisinins; Hot Temperature