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The origin of heredity in protocells

Abstract:

Here we develop a computational model that examines one of the first major biological innovations-the origin of heredity in simple protocells. The model assumes that the earliest protocells were autotrophic, producing organic matter from CO2 and H2 Carbon fixation was facilitated by geologically sustained proton gradients across fatty acid membranes, via iron-sulfur nanocrystals lodged within the membranes. Thermodynamic models suggest that organics formed this way should include amino acids ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rstb.2016.0419

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-4628-0303
More by this author
Role:
Author
ORCID:
0000-0002-5779-6543
More by this author
Role:
Author
ORCID:
0000-0002-5171-8755
More by this author
Role:
Author
ORCID:
0000-0002-5433-3973
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Journal website
Volume:
372
Issue:
1735
Article number:
20160419
Publication date:
2017-12-05
Acceptance date:
2017-07-25
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
Pmid:
29061892
Language:
English
Keywords:
Pubs id:
970979
Local pid:
pubs:970979
Deposit date:
2020-07-17

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