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The role of thymic tolerance in CNS autoimmune disease

Abstract:

The contributions of the peripheral adaptive and innate immune systems to CNS autoimmunity have been extensively studied. However, the role of thymic selection in these conditions is much less well understood. The thymus is the primary lymphoid organ for the generation of T cells; thymic mechanisms ensure that cells with an overt autoreactive specificity are eliminated before they emigrate to the periphery and control the generation of thymic regulatory T cells. Evidence from animal studies d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41582-018-0095-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Grant:
104079/Z/14/Z
105045/Z/14/Z
Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Neurology Journal website
Volume:
14
Issue:
12
Pages:
723–734
Publication date:
2018-11-19
Acceptance date:
2018-08-31
DOI:
EISSN:
1759-4766
ISSN:
1759-4758
Pubs id:
pubs:929177
URN:
uri:3c1a9da0-9db8-484d-a214-ed25f7260b9e
UUID:
uuid:3c1a9da0-9db8-484d-a214-ed25f7260b9e
Local pid:
pubs:929177
Keywords:

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