Journal article
The role of thymic tolerance in CNS autoimmune disease
- Abstract:
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The contributions of the peripheral adaptive and innate immune systems to CNS autoimmunity have been extensively studied. However, the role of thymic selection in these conditions is much less well understood. The thymus is the primary lymphoid organ for the generation of T cells; thymic mechanisms ensure that cells with an overt autoreactive specificity are eliminated before they emigrate to the periphery and control the generation of thymic regulatory T cells. Evidence from animal studies d...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1.3MB)
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- Publisher copy:
- 10.1038/s41582-018-0095-7
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Reviews Neurology Journal website
- Volume:
- 14
- Issue:
- 12
- Pages:
- 723–734
- Publication date:
- 2018-11-19
- Acceptance date:
- 2018-08-31
- DOI:
- EISSN:
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1759-4766
- ISSN:
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1759-4758
- Source identifiers:
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929177
Item Description
- Keywords:
- Pubs id:
-
pubs:929177
- UUID:
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uuid:3c1a9da0-9db8-484d-a214-ed25f7260b9e
- Local pid:
- pubs:929177
- Deposit date:
- 2018-10-18
Terms of use
- Copyright holder:
- Handel, et al
- Copyright date:
- 2018
- Notes:
- © Handel, et al, 2018 This is the accepted manuscript version of the article. The final version is available online from Springer Nature at https://doi.org/10.1038/s41582-018-0095-7
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