- Abstract:
-
The contributions of the peripheral adaptive and innate immune systems to CNS autoimmunity have been extensively studied. However, the role of thymic selection in these conditions is much less well understood. The thymus is the primary lymphoid organ for the generation of T cells; thymic mechanisms ensure that cells with an overt autoreactive specificity are eliminated before they emigrate to the periphery and control the generation of thymic regulatory T cells. Evidence from animal studies d...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.3MB)
-
- Publisher copy:
- 10.1038/s41582-018-0095-7
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Reviews Neurology Journal website
- Volume:
- 14
- Issue:
- 12
- Pages:
- 723–734
- Publication date:
- 2018-11-19
- Acceptance date:
- 2018-08-31
- DOI:
- EISSN:
-
1759-4766
- ISSN:
-
1759-4758
- Pubs id:
-
pubs:929177
- URN:
-
uri:3c1a9da0-9db8-484d-a214-ed25f7260b9e
- UUID:
-
uuid:3c1a9da0-9db8-484d-a214-ed25f7260b9e
- Local pid:
- pubs:929177
- Keywords:
- Copyright holder:
- Handel, et al
- Copyright date:
- 2018
- Notes:
- © Handel, et al, 2018 This is the accepted manuscript version of the article. The final version is available online from Springer Nature at https://doi.org/10.1038/s41582-018-0095-7
Journal article
The role of thymic tolerance in CNS autoimmune disease
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