Journal article icon

Journal article

The role of thymic tolerance in CNS autoimmune disease

Abstract:

The contributions of the peripheral adaptive and innate immune systems to CNS autoimmunity have been extensively studied. However, the role of thymic selection in these conditions is much less well understood. The thymus is the primary lymphoid organ for the generation of T cells; thymic mechanisms ensure that cells with an overt autoreactive specificity are eliminated before they emigrate to the periphery and control the generation of thymic regulatory T cells. Evidence from animal studies d...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41582-018-0095-7

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Neurology Journal website
Volume:
14
Issue:
12
Pages:
723–734
Publication date:
2018-11-19
Acceptance date:
2018-08-31
DOI:
EISSN:
1759-4766
ISSN:
1759-4758
Source identifiers:
929177
Keywords:
Pubs id:
pubs:929177
UUID:
uuid:3c1a9da0-9db8-484d-a214-ed25f7260b9e
Local pid:
pubs:929177
Deposit date:
2018-10-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP