Journal article
Inositol adenophostin: convergent synthesis of a potent agonist of D-myo-inositol 1,4,5-trisphosphate receptors
- Abstract:
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D-myo-Inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP3Rs. A recent synthesis of D-chiro-inositol adenophostin (InsAdA, 5) employed suitably- protected chiral building blocks and replaced the d-glucose core by d-chiro-inositol. An alternative approach to fully chiral material is now reported using intrinsic sugar chirality to av...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1021/acsomega.0c04145
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Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- ACS Omega More from this journal
- Volume:
- 5
- Issue:
- 44
- Pages:
- 28793–28811
- Publication date:
- 2020-10-28
- Acceptance date:
- 2020-10-08
- DOI:
- EISSN:
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2470-1343
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1136453
- Local pid:
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pubs:1136453
- Deposit date:
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2020-10-08
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- ©2020 American Chemical Society
- Notes:
- This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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