Journal article : Review
The role of snare proteins in cortical development
- Abstract:
- Neural communication in the adult nervous system is mediated primarily through chemical synapses, where action potentials elicit Ca2+ signals, which trigger vesicular fusion and neurotransmitter release in the presynaptic compartment. At early stages of development, the brain is shaped by communication via trophic factors and other extracellular signaling, and by contact-mediated cell–cell interactions including chemical synapses. The patterns of early neuronal impulses and spontaneous and regulated neurotransmitter release guide the precise topography of axonal projections and contribute to determining cell survival. The study of the role of specific proteins of the synaptic vesicle release machinery in the establishment, plasticity, and maintenance of neuronal connections during development has only recently become possible, with the advent of mouse models where various members of the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex have been genetically manipulated. We provide an overview of these models, focusing on the role of regulated vesicular release and/or cellular excitability in synaptic assembly, development and maintenance of cortical circuits, cell survival, circuit level excitation–inhibition balance, myelination, refinement, and plasticity of key axonal projections from the cerebral cortex. These models are important for understanding various developmental and psychiatric conditions, and neurodegenerative diseases.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.4MB, Terms of use)
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- Publisher copy:
- 10.1002/dneu.22892
Authors
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- G0700377
- MR/N026039/1
+ Biotechnology and Biological Sciences Research Council
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- Funder identifier:
- https://ror.org/00cwqg982
- Grant:
- BB/I021833/1
- Publisher:
- Wiley
- Journal:
- Developmental Neurobiology More from this journal
- Volume:
- 82
- Issue:
- 6
- Pages:
- 457-475
- Place of publication:
- United States
- Publication date:
- 2022-07-05
- Acceptance date:
- 2022-05-25
- DOI:
- EISSN:
-
1932-846X
- ISSN:
-
1932-8451
- Pmid:
-
35724379
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1264851
- Local pid:
-
pubs:1264851
- Deposit date:
-
2024-02-21
- ARK identifier:
Terms of use
- Copyright holder:
- Vadisiute et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Developmental Neurobiology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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