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Hot spots in Tcf4 for the interaction with beta-catenin.

Abstract:

The interaction of beta-catenin with T-cell factor (Tcf) 4 plays a central role in the Wnt signaling pathway and has been discussed as a possible site of intervention for the development of anti-cancer drugs. In this study, we performed Ala-scanning mutagenesis of all Tcf4 residues in the Tcf-beta-catenin interface and studied the binding energetics of these mutants using isothermal titration calorimetry. Binding of Tcf4 was found to be highly cooperative. Single site mutations of most Tcf4 r...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m301781200

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Journal:
Journal of biological chemistry
Volume:
278
Issue:
23
Pages:
21092-21098
Publication date:
2003-06-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
108680

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