Journal article
Neuroanatomical localization of faciobrachial dystonic seizures in LGI1-antibody encephalitis
- Abstract:
- Faciobrachial dystonic seizures (FBDS), paroxysmal dizziness spells, and thermal sensory attacks are highly frequent and stereotypic phenomena experienced in leucine-rich glioma inactivated 1 (LGI1)-antibody encephalitis. This study aims to describe the electrophysiologic mechanism underlying these pathognomonic symptoms. LGI1-antibody encephalitis patients with active symptoms were enrolled from two separate centers in South Korea and the United States. Patients were evaluated with simultaneous magnetoencephalography (306 channels) and electroencephalography. Regional alterations in neuronal excitability represented by interictal epileptiform discharges were present in the faciobrachial area of the motor cortex, insula, and somatosensory cortex, somatotopically aligned with each of the ictal semiologies observed in patients. FBDS and other LGI1-antibody encephalitis-specific spells localized to cortical regions neuroanatomically corresponding to ictal semiologies: the faciobrachial homunculus (FBDS), insular cortex (paroxysmal dizziness spells), and somatosensory cortex (thermal sensory attacks). Our findings support the ictal hypothesis underlying these unique phenomena.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 68.2KB, Terms of use)
-
- Publisher copy:
- 10.1002/epi.70197
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 104079/Z/14/Z
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/V007173/1
+ Ministry of Science and ICT
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- Funder identifier:
- https://ror.org/01wpjm123
- Grant:
- RS‐2025‐00519112
+ Korea Health Industry Development Institute
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- Funder identifier:
- https://ror.org/00fdzyk40
- Grant:
- RS‐2023‐00266044
- Publisher:
- Wiley
- Journal:
- Epilepsia: Official journal of the International League Against Epilepsy More from this journal
- Article number:
- epi.70197
- Publication date:
- 2026-03-13
- Acceptance date:
- 2026-02-26
- DOI:
- EISSN:
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1528-1167
- ISSN:
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0013-9580
- Language:
-
English
- Keywords:
- Pubs id:
-
2391687
- Local pid:
-
pubs:2391687
- Source identifiers:
-
W7135239041
- Deposit date:
-
2026-03-20
- ARK identifier:
Terms of use
- Copyright holder:
- International League Against Epilepsy.
- Copyright date:
- 2026
- Rights statement:
- © 2026 International League Against Epilepsy.
- Notes:
- The author accepted manuscript (AAM) of this paper has been made available under the University of Oxford's Open Access Publications Policy, and a CC BY public copyright licence has been applied.
- Licence:
- CC Attribution (CC BY)
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