Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers.

Journal article

BACKGROUND: The role of FOXP1 in sporadic breast cancers has been widely studied but its role in familial breast cancers is yet unexplored. AIMS: To investigate FOXP1 expression in different molecular subtypes of familial breast cancers and to correlate its expression with clinicopathological parameters, oestrogen receptors (ER) and survival. METHODS: Immunohistochemical staining for FOXP1 was performed in 126 familial breast carcinomas comprising 35 BRCA1, 34 BRCA2 and 57 BRCAX. RESULTS: Nu...

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Authors: Rayoo, M; Yan, M; Takano, E; Bates, G; Brown, P

• Publication status: Published
• Journal: Journal of clinical pathology
• Volume: 62
• Issue: 10
• Pages: 896-902
• Publication date: 2009-10-01
• DOI: 10.1136/jcp.2009.065169
• EISSN: 1472-4146
• ISSN: 0021-9746
• Language: English
• Keywords: Middle Aged; Neoplasm Proteins; Aged; BRCA1 Protein; Adult; Apoptosis Regulatory Proteins; BRCA2 Protein; Survival Analysis; Phenotype; Retrospective Studies; Tumor Markers, Biological; Repressor Proteins; Estrogen Receptor alpha; Prognosis; Forkhead Transcription Factors; Humans; Estrogen Receptor beta; Genetic Predisposition to Disease; Breast Neoplasms; Female