Cardiac electrophysiological imaging systems scalable for high-throughput drug testing

Journal article

Multi-parametric electrophysiological measurements using optical methods have become a highly valued standard in cardiac research. Most published optical mapping systems are expensive and complex. Although some applications demand high-cost components and complex designs, many can be tackled with simpler solutions. Here, we describe (1) a camera-based voltage and calcium imaging system using a single 'economy' electron-multiplying charge-coupled device camera and demonstrate the possibility o...

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Authors: Lee, P; Wang, K; Woods, C; Yan, P; Kohl, P

• Journal: Pflugers Archiv European Journal of Physiology
• Volume: 464
• Issue: 6
• Pages: 645-656
• Publication date: 2012-12-01
• DOI: 10.1007/s00424-012-1149-0
• EISSN: 1432-2013
• ISSN: 0031-6768
• Language: English
• Keywords: Highthroughput; Voltage and calcium-sensitive dyes; High-speed imaging; Cardiac; Multi-parametric; Drug testing; Fluorescence; Optical mapping