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A turn-on fluorescent iron complex and its cellular uptake.

Abstract:

In the treatment of chronic iron overload disorders, ligands capable of complexing so-called "labile" (nonprotein bound) Fe are required to enter iron-loaded cells, sequester excess Fe, and then exit the cell (and the body) as an intact Fe complex. Despite the emergence of several ligand families that show high activity in mobilizing intracellular Fe, the mechanism and the locations of these subcellular labile Fe pools are still poorly understood. Our previous studies have unearthed a class o...

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Publication status:
Published

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Publisher copy:
10.1021/ic201495r

Authors


Chartres, JD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Bernhardt, PV More by this author
Journal:
Inorganic chemistry
Volume:
50
Issue:
18
Pages:
9178-9183
Publication date:
2011-09-05
DOI:
EISSN:
1520-510X
ISSN:
0020-1669
URN:
uuid:3ba70569-646d-451c-ab39-edcc10684ed7
Source identifiers:
177417
Local pid:
pubs:177417

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