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VEGF signals induce trailblazer cell identity that drives neural crest migration.

Abstract:

Embryonic neural crest cells travel in discrete streams to precise locations throughout the head and body. We previously showed that cranial neural crest cells respond chemotactically to vascular endothelial growth factor (VEGF) and that cells within the migratory front have distinct behaviors and gene expression. We proposed a cell-induced gradient model in which lead neural crest cells read out directional information from a chemoattractant profile and instruct trailers to follow. In this s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ydbio.2015.08.011

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Funding agency for:
Schumacher, L
Grant:
EP/F500394/1
Publisher:
Elsevier Publisher's website
Journal:
Developmental Biology Journal website
Volume:
407
Issue:
1
Pages:
12-25
Publication date:
2015-08-13
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
Source identifiers:
539603
Language:
English
Keywords:
Pubs id:
pubs:539603
UUID:
uuid:3b996e9d-077b-471d-b47c-f7964811749f
Local pid:
pubs:539603
Deposit date:
2016-02-10

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