Diagnostic fine-needle aspiration cytology and immunocytochemistry analysis of a primary thyroid lymphoma presenting as an anatomic emergency.

Journal article

The case of a 66-year-old woman with rapidly progressive respiratory distress caused by a massive anterior neck mass with tracheal compression is presented. Within 24 hours, fine-needle aspiration cytology (FNAC) and immunocytochemistry provided a diagnosis of high-grade B-cell lymphoma and the opportunity to institute a chemotherapeutic regimen resulting in a rapid volume reduction and airway expansion. One year after combined modality treatment the patient was in complete remission (with an estimated thyroid volume of 4 cm3). This case report illustrates the advantages of FNAC and immunocytochemistry in the diagnosis of thyroid lymphoma.

Authors: Van den Bruel, A; Drijkoningen, M; Oyen, R; Vanfleteren, E; Bouillon, R

• Journal: Thyroid : official journal of the American Thyroid Association
• Volume: 12
• Issue: 2
• Pages: 169-173
• Publication date: 2002-02-01
• DOI: 10.1089/105072502753522419
• EISSN: 1557-9077
• ISSN: 1050-7256
• Language: English
• Keywords: Cyclophosphamide; Neoplasm Staging; Tomography, X-Ray Computed; Aged; Humans; Thyroid Neoplasms; Immunohistochemistry; Laryngoscopy; Lymphoma, Large B-Cell, Diffuse; Biopsy, Needle; Prednisone; Doxorubicin; Lymphoma, B-Cell; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Follow-Up Studies; Female; Vincristine