Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Journal article

The molecular repertoire of macrophages in health and disease can provide novel biomarkers for diagnosis, prognosis, and treatment. Th2-IL-4–activated macrophages (M2) have been associated with important diseases in mice, yet no specific markers are available for their detection in human tissues. Although mouse models are widely used for macrophage research, translation to the human can be problematic and the human macrophage system remains poorly described. In the present study, we analyzed ...

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Authors: Martinez, F; Helming, L; Milde, R; Varin, A; Melgert, B

• Publication status: Published
• Journal: Blood
• Volume: 121
• Issue: 9
• Pages: e57-e69
• Publication date: 2013-02-01
• DOI: 10.1182/blood-2012-06-436212
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Macrophages; Cell Proliferation; Species Specificity; Cluster Analysis; Proteome; Humans; Cells, Cultured; Mice, Inbred C57BL; Gene Expression Profiling; Macrophage Activation; Transcriptome; Animals; Models, Biological; Interleukin-4; Mice