- Abstract:
-
Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon–carbon bonds in the pharmaceutical industry, the Suzuki–Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.3MB)
-
- Publisher copy:
- 10.1039/C7SC00675F
-
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 8
- Issue:
- 6
- Pages:
- 4437-4442
- Publication date:
- 2017-04-28
- Acceptance date:
- 2017-04-11
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
- Pubs id:
-
pubs:688985
- URN:
-
uri:3b6b3060-5c07-490b-84b0-63e100d46266
- UUID:
-
uuid:3b6b3060-5c07-490b-84b0-63e100d46266
- Local pid:
- pubs:688985
- Paper number:
- 6
- Copyright holder:
- Markovic et al.
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Journal article
Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides
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Funding
Pfizer, Inc.
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