Reshaping human antibodies for therapy.

Journal article

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

Authors: Riechmann, L; Clark, M; Waldmann, H; Winter, G

• Publication status: Published
• Journal: Nature
• Volume: 332
• Issue: 6162
• Pages: 323-327
• Publication date: 1988-03-01
• DOI: 10.1038/332323a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Recombinant Proteins; Immunoglobulin Heavy Chains; Antibodies, Monoclonal; Immunoglobulin G; Binding Sites, Antibody; Immunoglobulin Variable Region; Base Sequence; Rats; Lymphocytes; Humans; Molecular Sequence Data; Animals; Immunoglobulin Light Chains; Species Specificity; Recombinant Fusion Proteins; Amino Acid Sequence; Genes, Synthetic