A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.

Journal article

We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

Authors: Cooke, G; Tosh, K; Ramaley, P; Kaleebu, P; Zhuang, J

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 194
• Issue: 5
• Pages: 666-669
• Publication date: 2006-09-01
• DOI: 10.1086/505875
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Cohort Studies; HIV Seropositivity; HIV Seronegativity; Chemokine CCL5; Regression Analysis; Polymorphism, Genetic; Homozygote; Humans; Uganda; Treatment Outcome; Survival Analysis