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Controlling curvature in a family of oligoamide alpha-helix mimetics.

Abstract:
(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200803778

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English)
Volume:
47
Issue:
50
Pages:
9691-9694
Publication date:
2008-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:3b58d7c0-0765-404c-a16a-a1cdc3faa6de
Source identifiers:
117465
Local pid:
pubs:117465

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