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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

Abstract:

BACKGROUND: Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to identify sensitive and reliable biomarkers in premanifest carriers of mutated HTT and in individuals with early HD that could provide essential methodology for the assessment of therapeutic interventions. METHODS: This multicentre study uses an extensive battery of novel assessments, including multi-site 3T MRI, clinical, cogn...

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Publication status:
Published

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Authors


Tabrizi, SJ More by this author
Langbehn, DR More by this author
Leavitt, BR More by this author
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Journal:
The Lancet. Neurology
Volume:
8
Issue:
9
Pages:
791-801
Publication date:
2009-09-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:3b55aef0-e6d4-4530-804a-a7866e85bad1
Source identifiers:
119667
Local pid:
pubs:119667

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