Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models.

Journal article

The heart is structurally and functionally a highly non-homogenous organ, yet its main function as a pump can only be achieved by the co-ordinated contraction of millions of ventricular cells. This apparent contradiction gives rise to the hypothesis that 'well-organised' inhomogeneity may be a pre-requisite for normal cardiac function. Here, we present a set of novel experimental and theoretical tools for the study of this concept. Heterogeneity, in its most condensed form, can be simulated u...

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Authors: Markhasin, V; Solovyova, O; Katsnelson, L; Protsenko, Y; Kohl, P

• Publication status: Published
• Journal: Progress in biophysics and molecular biology
• Volume: 82
• Issue: 1-3
• Pages: 207-220
• Publication date: 2003-01-01
• DOI: 10.1016/s0079-6107(03)00017-8
• EISSN: 1873-1732
• ISSN: 0079-6107
• Language: English
• Keywords: Animals; Heart; Heart Conduction System; Humans; Models, Cardiovascular; Electrophysiology; Myocardium; Models, Theoretical; Time Factors