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A meta-analysis of temporal changes of response in the placebo arm of surgical randomized controlled trials: an update

Abstract:

Background

Temporal changes in the placebo arm of randomized controlled trials (RCTs) have not been thoroughly investigated, despite the fact that results of RCTs depend on the comparison between arms.

Methods

In this update of our earlier systematic review and meta-analysis, we set out to investigate the effect of assessment time and number of visits on the magnitude of change from baseline in the placebo arm of these trials. We used linear mixed-effects models t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-017-2070-9

Authors


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Department:
Oxford, MSD, NDORMS
More by this author
Department:
Oxford, MSD, NDORMS, KIR
Feakins, BG More by this author
More by this author
Department:
Oxford, MSD, NDORMS, KIR
More by this author
Department:
Oxford, MSD, NDORMS, KIR
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National Institute for Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Publication date:
2017-07-05
Acceptance date:
2017-06-27
DOI:
EISSN:
1745-6215
Pubs id:
pubs:707860
URN:
uri:3b473d98-a35c-4a19-86a9-35c5d2a8a793
UUID:
uuid:3b473d98-a35c-4a19-86a9-35c5d2a8a793
Local pid:
pubs:707860

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