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Journal article

DOCK8 is critical for the survival and function of NKT cells.

Abstract:

Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infections, hyper-immunoglobulin E levels, eczema, and greater susceptibility to cancer. Because natural killer T (NKT) cells have been implicated in these diseases, we asked if these cells were affected by DOCK8 deficiency. Using a mouse model, we found that DOCK8 deficiency resulted in impaired NKT cell development, principally affecting the formation and survival of long...

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Publication status:
Published

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Authors


Crawford, G More by this author
Gileadi, U More by this author
Stankovic, S More by this author
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Journal:
Blood
Volume:
122
Issue:
12
Pages:
2052-2061
Publication date:
2013-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3b44408b-8379-408a-b39d-ae15afaebfb0
Source identifiers:
418353
Local pid:
pubs:418353

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