Conference item

Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study

Abstract:: Interleukin-17A (IL-17) is a pro-inflammator¬y cytokine, which has been reported to be increased in the joint of patients with OA. This study aimed to identify whether IL-17 or its receptors are expressed in the joints of OA patients and establish the effect of IL-17 in vitro on primary human chondrocytes and synovial fibroblasts from the joints of OA patients. We further studied whether any anti-inflammatory agents in current clinical use were able to reduce the effects of IL-17. We hypothesize that IL-17 stimulates the production of matrix degrading and inflammatory proteins by acting on IL-17 receptors on chondrocytes and synovial fibroblasts, which can be blocked by clinically used anti-inflammatory therapeutics.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Mimpen, J., Carr, A., Dakin, S., & Snelling, S. (2018). Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study. Osteoarthritis and Cartilage, 26(S1), S118 .

MLA Style

Mimpen, J., et al. “Inhibition of Interleukin-17-Induced Effects in Osteoarthritis - An in Vitro Study.” Osteoarthritis and Cartilage, vol. 26, no. S1, Elsevier, 2018, p. S118 .

Chicago Style

Mimpen, J, A Carr, S Dakin, and S Snelling. 2018. “Inhibition of Interleukin-17-Induced Effects in Osteoarthritis - An in Vitro Study.” In Osteoarthritis and Cartilage, 26:S118 . Elsevier.
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Files:: OARSI abstract_Mimpen.pdf

(Preview, Accepted manuscript, pdf, 335.1KB, Terms of use)

Publisher copy:: 10.1016/j.joca.2018.02.258

Authors

+ Mimpen, J More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: NDORMS
Role:: Author

+ Carr, A More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: NDORMS
Role:: Author

+ Dakin, S More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: NDORMS
Role:: Author

+ Snelling, S More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: NDORMS
Oxford college:: Keble College
Role:: Author

Publisher:: Elsevier
Host title:: Osteoarthritis and Cartilage
Journal:: Osteoarthritis and Cartilage More from this journal
Volume:: 26
Issue:: S1
Pages:: S118
Publication date:: 2018-04-16
Acceptance date:: 2018-01-16
DOI:: 10.1016/j.joca.2018.02.258
ISSN:: 1522-9653 and 1063-4584

Pubs id:: pubs:856203
UUID:: uuid:3b395af8-ef76-4f65-bf1b-525a38e1e0c5
Local pid:: pubs:856203
Source identifiers:: 856203
Deposit date:: 2018-07-26

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2018
Notes:: © 2018 Published by Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.joca.2018.02.258

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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