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Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation

Abstract:

Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglycans (GAGs) is required and therefore this interaction represents a potential target for therapeutic intervention. We have designed an anti-inflammatory decoy variant, Met-CCL2 (Y13A S21K Q23R), embodying increased affinity for GAGs as well as knocked...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.neulet.2016.05.037

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
ORCID:
0000-0001-8869-5924
More by this author
ORCID:
0000-0002-7588-0415
Austrian Academy of Sciences More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Neuroscience Letters Journal website
Volume:
626
Pages:
164-173
Publication date:
2016-05-19
Acceptance date:
2016-05-18
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
Pubs id:
pubs:855518
URN:
uri:3b1e2019-f98b-4b84-8ab7-ffbb95e6b43f
UUID:
uuid:3b1e2019-f98b-4b84-8ab7-ffbb95e6b43f
Local pid:
pubs:855518

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