Journal article
Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation
- Abstract:
-
Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglycans (GAGs) is required and therefore this interaction represents a potential target for therapeutic intervention. We have designed an anti-inflammatory decoy variant, Met-CCL2 (Y13A S21K Q23R), embodying increased affinity for GAGs as well as knocked...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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(pdf, 1.3MB)
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- Publisher copy:
- 10.1016/j.neulet.2016.05.037
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Authors
Funding
Austrian Academy of Sciences
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neuroscience Letters Journal website
- Volume:
- 626
- Pages:
- 164-173
- Publication date:
- 2016-05-19
- Acceptance date:
- 2016-05-18
- DOI:
- EISSN:
-
1872-7972
- ISSN:
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0304-3940
- Pubs id:
-
pubs:855518
- URN:
-
uri:3b1e2019-f98b-4b84-8ab7-ffbb95e6b43f
- UUID:
-
uuid:3b1e2019-f98b-4b84-8ab7-ffbb95e6b43f
- Local pid:
- pubs:855518
- Paper number:
- C
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Elsevier Ireland Ltd
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Ireland Ltd. All rights reserved.
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