Journal article
Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation
- Abstract:
-
Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglycans (GAGs) is required and therefore this interaction represents a potential target for therapeutic intervention. We have designed an anti-inflammatory decoy variant, Met-CCL2 (Y13A S21K Q23R), embodying increased affinity for GAGs as well as knocked...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Accepted manuscript, pdf, 1.3MB)
-
- Publisher copy:
- 10.1016/j.neulet.2016.05.037
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Austrian Academy of Sciences
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neuroscience Letters Journal website
- Volume:
- 626
- Pages:
- 164-173
- Publication date:
- 2016-05-19
- Acceptance date:
- 2016-05-18
- DOI:
- EISSN:
-
1872-7972
- ISSN:
-
0304-3940
- Pmid:
-
27212623
- Source identifiers:
-
855518
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:855518
- UUID:
-
uuid:3b1e2019-f98b-4b84-8ab7-ffbb95e6b43f
- Local pid:
- pubs:855518
- Deposit date:
- 2018-06-07
Terms of use
- Copyright holder:
- Elsevier Ireland Ltd
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Ireland Ltd. All rights reserved.
If you are the owner of this record, you can report an update to it here: Report update to this record