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Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci.

Abstract:

Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-related traits Consortium. Discovery was performed in 16,753 individuals, and replication was attempt...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2337/db16-0199

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Publication date:
2016-07-14
Acceptance date:
2016-07-05
DOI:
ISSN:
1939-327X and 0012-1797
Pubs id:
pubs:635409
URN:
uri:3b1318ad-dd5d-4ba6-9d68-f95de140a846
UUID:
3b1318ad-dd5d-4ba6-9d68-f95de140a846
Local pid:
pubs:635409
Language:
English
Keywords:

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