Regulation of influenza a virus nucleoprotein oligomerization by phosphorylation.

Journal article

In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by reversible phosphorylation.

Authors: Turrell, L; Hutchinson, E; Vreede, F; Fodor, E

• Journal: Journal of virology
• Volume: 89
• Issue: 2
• Pages: 1452-1455
• Publication date: 2015-01-01
• DOI: 10.1128/jvi.02332-14
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English