Journal article

Regulation of influenza a virus nucleoprotein oligomerization by phosphorylation.

Abstract:: In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by reversible phosphorylation.

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Turrell, L., Hutchinson, E., Vreede, F., & Fodor, E. (2015). Regulation of influenza a virus nucleoprotein oligomerization by phosphorylation. Journal of Virology, 89(2), 1452–1455.

MLA Style

Turrell, L., et al. “Regulation of Influenza a Virus Nucleoprotein Oligomerization by Phosphorylation.” Journal of Virology, vol. 89, no. 2, 2015, pp. 1452–55.

Chicago Style

Turrell, L., E. Hutchinson, F. Vreede, and E. Fodor. 2015. “Regulation of Influenza a Virus Nucleoprotein Oligomerization by Phosphorylation.” Journal of Virology 89 (2): 1452–55.
Print

Access Document

Publisher copy:: 10.1128/jvi.02332-14

Authors

+ Turrell, L More by this author

Role:: Author

+ Hutchinson, E More by this author

Role:: Author

+ Vreede, F More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pathology Dunn School
Role:: Author

+ Fodor, E More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pathology Dunn School
Role:: Author

Journal:: Journal of virology More from this journal
Volume:: 89
Issue:: 2
Pages:: 1452-1455
Publication date:: 2015-01-01
DOI:: 10.1128/jvi.02332-14
EISSN:: 1098-5514
ISSN:: 0022-538X

Language:: English
Pubs id:: pubs:488355
UUID:: uuid:3ae94fcb-49c1-4383-89c3-0a78dfae35c4
Local pid:: pubs:488355
Source identifiers:: 488355
Deposit date:: 2014-11-04
ARK identifier:: ark:/29072/ora_3ae94fcb49c1438389c30a78dfae35c4

Terms of use

Copyright date:: 2015

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

Views and downloads will return soon

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP