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JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Abstract:: Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the study of these chronic myeloid malignancies provides an experimentally tractable approach to understanding early tumorigenesis. Introduction of e...
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Publication status:: Published

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APA Style

Chen, E., Ahn, J., Massie, C., Clynes, D., Godfrey, A., Li, J., Park, H., Nangalia, J., Silber, Y., Mullally, A., Gibbons, R., & Green, A. (2014). JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response. Proceedings of the National Academy of Sciences of the United States of America, 111(42), 15190–15195.

MLA Style

Chen, E., et al. “JAK2V617F Promotes Replication Fork Stalling with Disease-Restricted Impairment of the Intra-S Checkpoint Response.” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 42, National Academy of Sciences, 2014, pp. 15190–95.

Chicago Style

Chen, E, J Ahn, C Massie, D Clynes, A Godfrey, J Li, H Park, et al. 2014. “JAK2V617F Promotes Replication Fork Stalling with Disease-Restricted Impairment of the Intra-S Checkpoint Response.” Proceedings of the National Academy of Sciences of the United States of America 111 (42): 15190–95.
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Publisher copy:: 10.1073/pnas.1401873111

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+ Chen, E More by this author

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+ Ahn, J More by this author

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+ Massie, C More by this author

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+ Clynes, D More by this author

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+ Godfrey, A More by this author

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Bibliographic Details

Publisher:: National Academy of Sciences
Journal:: Proceedings of the National Academy of Sciences of the United States of America
Volume:: 111
Issue:: 42
Pages:: 15190-15195
Publication date:: 2014-10-01
DOI:: 10.1073/pnas.1401873111
EISSN:: 1091-6490
ISSN:: 0027-8424

Item Description

Language:: English
Keywords:: myeloproliferative neoplasm

replication stress

JAK2V617F
Pubs id:: pubs:486160
UUID:: uuid:3ad70471-b6be-4872-bc3e-d6fbcf03f2aa
Local pid:: pubs:486160
Source identifiers:: 486160
Deposit date:: 2014-10-13

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Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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