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Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.

Abstract:

Tetrameric peptide-MHC class I complexes ("tetramers") are proving invaluable as reagents for characterizing immune responses involving CTLs. However, because the TCR can exhibit a degree of promiscuity for binding peptide-MHC class I ligands, there is potential for cross-reactivity. Recent reports showing that the TCR/peptide-MHC interaction is dramatically dependent upon temperature led us to investigate the effects of incubation temperature on tetramer staining. We find that tetramers rapi...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
163
Issue:
8
Pages:
4342-4348
Publication date:
1999-10-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:3acd7bf9-2c52-4ca8-a8ad-93cf0aa4d269
Source identifiers:
13873
Local pid:
pubs:13873

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