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Lipid-lowering pretreatment and outcome following intravenous thrombolysis for acute ischaemic stroke: a post hoc analysis of the Enhanced Control Of Hypertension And Thrombolysis Stroke Study trial

Abstract:

Background: Debate exists as to whether statin pretreatment confers an increased risk of 90- day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis (IVT). We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup analysis of ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1159/000488911

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
National Health and Medical Research Council More from this funder
Stroke Association More from this funder
More from this funder
Grant:
467322/2014-7
402388/2013-5
Publisher:
Karger Publishers Publisher's website
Journal:
Cerebrovascular Diseases Journal website
Volume:
45
Issue:
5-6
Pages:
213–220
Publication date:
2018-04-27
Acceptance date:
2018-03-31
DOI:
EISSN:
1421-9786
ISSN:
1015-9770
Pubs id:
pubs:833758
URN:
uri:3acb151b-cbce-493a-8032-9bd94dea6a72
UUID:
uuid:3acb151b-cbce-493a-8032-9bd94dea6a72
Local pid:
pubs:833758

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