Journal article
Genomic analyses from non-invasive prenatal testing reveal genetic associations, patterns of viral infections, and Chinese population history
- Abstract:
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We analyze whole-genome sequencing data from 141,431 Chinese women generated for non-invasive prenatal testing (NIPT). We use these data to characterize the population genetic structure and to investigate genetic associations with maternal and infectious traits. We show that the present day distribution of alleles is a function of both ancient migration and very recent population movements. We reveal novel phenotype-genotype associations, including several replicated associations with height ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 521.3KB, Terms of use)
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- Publisher copy:
- 10.1016/j.cell.2018.08.016
Authors
Funding
+ South China University of Technology
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Grant:
Distinguished Young Scholar: 2017JQ017
+ Natural Science Foundation of Guangdong Province, China
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Grant:
2017A030306026
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Cell More from this journal
- Volume:
- 175
- Issue:
- 2
- Pages:
- 347-359
- Publication date:
- 2018-10-04
- Acceptance date:
- 2018-08-08
- DOI:
- EISSN:
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1097-4172
- ISSN:
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0092-8674
- Pmid:
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30290141
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:924011
- UUID:
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uuid:3abee683-a507-43aa-a358-a17cdb34d2d4
- Local pid:
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pubs:924011
- Source identifiers:
-
924011
- Deposit date:
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2018-10-12
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2018
- Notes:
- Copyright ©️ 2018 Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Cell Press at: https://doi.org/10.1016/j.cell.2018.08.016
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