The strategy of gene assignment using hybrids: the number of lines needed to exclude chance associations

Journal article

Many of the human gene assignments made so far have been based on associations between pairs of unselected markers or between markers and chromosomes in a presumed random series of independently derived hybrids. The question is often asked: how many hybrids must be studied in order to rule out a chance association? Calculations are presented which aim at providing at least an approximate answer to this question. The optimum number of human chromosomes per hybrid cell line is given for studying, on the average, the minimum number of lines.

Authors: Bengtsson, B; Bodmer, W

• Journal: Cytogenetics and Cell Genetics
• Volume: 14
• Issue: 3-6
• Pages: 62-66
• Publication date: 1975-01-01
• ISSN: 0301-0171
• Language: English