Journal article
Establishing a single-sex controlled human Schistosoma mansoni infection model for Uganda: protocol for safety and dose-finding trial
- Abstract:
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Control of schistosomiasis depends on a single drug, praziquantel, with variable cure rates, high reinfection rates, and risk of drug resistance. A vaccine could transform schistosomiasis control. Preclinical data show that vaccine development is possible, but conventional vaccine efficacy trials require high incidence, long-term follow-up, and large sample size. Controlled human infection studies (CHI) can provide early efficacy data, allowing the selection of optimal candidates for furth...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 558.4KB, Terms of use)
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- Publisher copy:
- 10.1093/immadv/ltad010
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Funding
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Immunotherapy Advances More from this journal
- Volume:
- 3
- Issue:
- 1
- Article number:
- ltad010
- Publication date:
- 2023-07-20
- Acceptance date:
- 2023-07-13
- DOI:
- EISSN:
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2732-4303
- Pmid:
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37538934
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1529561
- Local pid:
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pubs:1529561
- Deposit date:
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2023-12-06
Terms of use
- Copyright holder:
- Abaasa et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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