Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

Journal article

RATIONALE: Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but the relevance of polymorphism within these genes to the common phenotype of tuberculosis remains unclear. METHODS: A total of 1,301 individuals were included in a large, detailed study of West African populations with pulmonary tuberculosis. We investigated di...

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Authors: Cooke, G; Campbell, S; Sillah, J; Gustafson, P; Bah, B

• Publication status: Published
• Journal: American journal of respiratory and critical care medicine
• Volume: 174
• Issue: 3
• Pages: 339-343
• Publication date: 2006-08-01
• DOI: 10.1164/rccm.200601-088oc
• EISSN: 1535-4970
• ISSN: 1073-449X
• Language: English
• Keywords: Polymorphism, Single Nucleotide; Adult; Africa, Western; Alleles; Receptors, Interferon; Promoter Regions, Genetic; Tuberculosis, Pulmonary; Genotype; Genetic Variation; Logistic Models; Humans