Humanized anti-CD4 monoclonal antibody therapy of autoimmune and inflammatory disease.

Journal article

We have investigated the biological and therapeutic properties of a humanized anti-CD4 MoAb, hIgG1-CD4, in patients with refractory psoriasis and rheumatoid arthritis (RA). hIgG1-CD4 is a modulating, non-depleting MoAb, which induced a first-dose reaction in most patients treated. It provided brief symptomatic relief in both conditions, and psoriasis appeared easier to control with conventional agents after MoAb therapy. At the doses used, hIgG1-CD4 did not synergize therapeutically with the ...

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Authors: Isaacs, J; Burrows, N; Wing, M; Keogan, M; Rebello, P

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 110
• Issue: 2
• Pages: 158-166
• Publication date: 1997-11-01
• DOI: 10.1111/j.1365-2249.1997.tb08312.x
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Adolescent; Humans; Antibodies, Monoclonal; Arthritis, Rheumatoid; Adult; Middle Aged; Aged; Animals; Antibodies, Bispecific; Autoimmune Diseases; Female; Male; Antigens, CD4; Rats; Immunotherapy; Psoriasis