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Journal article

De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to faulty mRNA translation re-initiation.

Abstract:

Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to Denr impair the long-term positioning, dendritic arborization, and dendritic spine c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.04.090

Authors


Schleich, S More by this author
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Department of Health More from this funder
State Government of Victoria More from this funder
Australian Government More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
15
Issue:
10
Pages:
2251-2265
Publication date:
2016-05-05
Acceptance date:
2016-04-30
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:624913
URN:
uri:3a98e7a9-979e-407d-8270-6d18aefeb155
UUID:
uuid:3a98e7a9-979e-407d-8270-6d18aefeb155
Local pid:
pubs:624913

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