Journal article

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials

Abstract:: OBJECTIVE: To compare the effect of specific antidepressants with placebo on heart rate corrected QT interval (QTc) during the first eight weeks of treatment for major depressive disorder in adults, and to investigate whether antidepressant use is associated with early major cardiovascular adverse events (MACE). DESIGN: Individual participant data (IPD) network meta-regression and aggregate pairwise meta-analysis. DATA SOURCES: Individual and aggregate level data from randomised controlled tr...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Ostinelli, E. G., Capocci, S., Li, Z., Friederich, C., Mugnai, G., Pottegård, A., Ribichini, F. L., & Cipriani, A. (2026). QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials. The BMJ, 394, e100600–e100600.

MLA Style

Ostinelli, EG, et al. “QTc Changes and Early Major Adverse Cardiovascular Events Associated with Antidepressant Treatment for Major Depressive Disorder in Adults: Individual Participant Data Network Meta-Regression of Double Blind Randomised Trials.” The BMJ, vol. 394, 2026, pp. e100600–e100600.

Chicago Style

Ostinelli, EG, S Capocci, Z Li, et al. 2026. “QTc Changes and Early Major Adverse Cardiovascular Events Associated with Antidepressant Treatment for Major Depressive Disorder in Adults: Individual Participant Data Network Meta-Regression of Double Blind Randomised Trials.” The BMJ 394: e100600–e100600.
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Publisher copy:: 10.1136/bmj-2026-100600

Authors

+ Ostinelli, EG More by this author

Institution:: University of Oxford
Role:: Author
ORCID:: 0000-0002-8717-0832

+ Capocci, S More by this author

Role:: Author

+ Li, Z More by this author

Institution:: University of Oxford
Role:: Author
ORCID:: 0000-0001-9431-258X

+ Friederich, C More by this author

Institution:: University of Oxford
Role:: Author

+ Mugnai, G More by this author

Role:: Author
ORCID:: 0000-0003-4733-9418

More authors...

Publisher:: BMJ
Journal:: The BMJ More from this journal
Volume:: 394
Pages:: e100600-e100600
Publication date:: 2026-09-23
DOI:: 10.1136/bmj-2026-100600
EISSN:: 1756-1833
ISSN:: 1756-1833

Language:: English
Keywords:: glomerular filtration rate

vortioxetine

major adverse cardiovascular events

serum potassium

venlafaxine

placebo comparison

amitriptyline

major depressive disorder

escitalopram

QTc prolongation

antidepressants
Pubs id:: 2460885
Local pid:: pubs:2460885
Source identifiers:: W7214127960
Deposit date:: 2026-10-03
ARK identifier:: ark:/29072/ora_3a71d829e3f44b57a169d70692d96acd

Terms of use

Copyright date:: 2026

Licence:: CC Attribution (CC BY)

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