Journal article
Defining an ageing-related pathology, disease or syndrome: international consensus statement
- Abstract:
- Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 520.5KB, Terms of use)
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- Publisher copy:
- 10.1007/s11357-024-01315-9
Authors
Contributors
+ Antoniades, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Clinical Neurosciences
- Oxford college:
- Brasenose College
- Role:
- Contributor
- ORCID:
- 0000-0002-1192-3834
et al.
- Publisher:
- Springer
- Host title:
- medRxiv
- Journal:
- GeroScience More from this journal
- Volume:
- 47
- Issue:
- 2
- Pages:
- 1713–1720
- Publication date:
- 2024-09-21
- Acceptance date:
- 2024-08-09
- DOI:
- EISSN:
-
2509-2723
- ISSN:
-
2509-2715
- Language:
-
English
- Keywords:
- Pubs id:
-
2026888
- Local pid:
-
pubs:2026888
- Deposit date:
-
2024-10-09
Terms of use
- Copyright holder:
- Short et al.
- Copyright date:
- 2024
- Rights statement:
- © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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