Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

Journal article

OBJECTIVE: To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. METHODS AND RESULTS: Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health200...

Expand abstract

Authors: Kiechl, S; Laxton, R; Xiao, Q; Hernesniemi, J; Raitakari, O

• Publication status: Published
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Volume: 30
• Issue: 12
• Pages: 2678-2683
• Publication date: 2010-12-01
• DOI: 10.1161/atvbaha.110.213785
• EISSN: 1524-4636
• ISSN: 1079-5642
• Language: English
• Keywords: Adult; Finland; Tunica Media; Coronary Artery Disease; Biological Markers; Aged; Genetic Predisposition to Disease; Chemokine CXCL12; Polymorphism, Single Nucleotide; Chromosomes, Human, Pair 10; Tunica Intima; Carotid Artery, Common; Odds Ratio; Male; Risk Assessment; Risk Factors; Regression Analysis; Humans; Carotid Artery Diseases; Gene Frequency; Austria; Young Adult; Aged, 80 and over; Female; Middle Aged; Phenotype; Stem Cells; Endothelial Cells; England