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Journal article

Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

Abstract:

OBJECTIVE: To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. METHODS AND RESULTS: Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health200...

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Publication status:
Published

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Publisher copy:
10.1161/atvbaha.110.213785

Authors


Laxton, RC More by this author
Hernesniemi, JA More by this author
Raitakari, OT More by this author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
30
Issue:
12
Pages:
2678-2683
Publication date:
2010-12-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:3a336763-4d74-4aa7-b26c-9a6ad4fb0f31
Source identifiers:
104324
Local pid:
pubs:104324

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