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The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.

Abstract:

We have assessed whether viscoelastic gels known to inhibit mucociliary clearance can increase lipid-mediated gene transfer. Methylcellulose or carboxymethylcellulose (0.25-1.5%) was mixed with complexes of the cationic lipid GL67A and plasmids encoding luciferase and perfused onto the nasal epithelium of mice. Survival after perfusion with 1% CMC or 1% MC was 90 and 100%, respectively. In contrast 1.5% CMC was uniformly lethal likely due to the viscous solution blocking the airways. Perfusio...

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Publication status:
Published

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Journal:
Biomaterials
Volume:
31
Issue:
9
Pages:
2665-2672
Publication date:
2010-03-01
DOI:
EISSN:
1878-5905
ISSN:
0142-9612
Source identifiers:
246550

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