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Journal article

Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection.

Abstract:

Interleukin-10 (IL-10) plays a key role in regulating proinflammatory immune responses to infection but can interfere with pathogen clearance. Although IL-10 is upregulated throughout HIV-1 infection in multiple cell subsets, whether this is a viral immune evasion strategy or an appropriate response to immune activation is unresolved. Analysis of IL-10 production at the single cell level in 51 chronically infected subjects (31 antiretroviral (ART) naïve and 20 ART treated) showed that a subse...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201343646

Authors


Clutton, G More by this author
Hancock, G More by this author
Holloway, C More by this author
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Journal:
European journal of immunology
Volume:
43
Issue:
11
Pages:
2875-2885
Publication date:
2013-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3a15920e-5a7b-44de-9f48-fdcfffb2cabc
Source identifiers:
416267
Local pid:
pubs:416267

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