Thesis
The role of CRTH2+ CD8+ T cells in severe asthma
- Abstract:
-
Type 2 inflammation of the airways is present in most patients with asthma, and some patients with chronic obstructive pulmonary disease (COPD). The molecular drivers of the type 2 immune response include the cytokines IL-4, IL-5, and IL-13, produced by activated type 2 T helper (Th2) and type 2 cytotoxic T (Tc2) cells. Expression of the prostaglandin D2 (PGD2) receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) has been associated wit...
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Authors
Contributors
+ Hinks, T
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
New College
Role:
Supervisor
+ Xue, L
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Supervisor
+ Klenerman, P
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Supervisor
ORCID:
0000-0003-4307-9161
+ Pavord, I
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
St Edmund Hall
Role:
Supervisor
+ Durham, S
Institution:
Faculty of Medicine at the National Heart & Lung Institute, Imperial College London
Role:
Examiner
Funding
+ Medical Research Council
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Grant:
BRT00030
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2022-01-17
Related Items
Terms of use
- Copyright holder:
- Hoyle, RD
- Copyright date:
- 2021
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