Thesis
The role of TLDc proteins in neuroinflammation
- Abstract:
-
The TLDc domain defines a family of proteins, including OXR1 and NCOA7, which are crucial for neuronal function1,2. Disruption or loss-of-function (LOF) mutations in these proteins are linked to neurological disorders such as intellectual disability, ataxia, and autism spectrum disorder (ASD)3–5. Additionally, TLDc proteins have been implicated in inflammatory responses, evidenced by pronounced microglial activation in Oxr1-/- mice6, and...
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Authors
Contributors
+ Oliver, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
+ Cowley, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pathology Dunn School
- Role:
- Supervisor
- ORCID:
- 0000-0003-0297-6675
+ James, W
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pathology Dunn School
- Role:
- Supervisor
- ORCID:
- 0000-0002-2506-1198
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Programme:
- Oxford-MRC DTP
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2025-03-24
Terms of use
- Copyright holder:
- Dominic Shaun Andrew Simpson
- Copyright date:
- 2024
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