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Journal article

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

Abstract:

Several recent ion channel structures have revealed large side portals, or ‘fenestrations’ at the interface between their transmembrane helices that potentially expose the ion conduction pathway to the lipid core of the bilayer. In a recent study we demonstrated that functional activity of the TWIK-1 K2P channel is influenced by the presence of hydrophobic residues deep within the inner pore. These residues are located near the fenestrations in the TWIK-1 structure and promote dewetting of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4161/19336950.2014.981987

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
OXION Initiative in Ion Channels and Disease
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Research group:
OXION Initiative in Ion Channels and Disease
Role:
Author
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Funding agency for:
Abd-Wahab, F
Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Pfizer Neusentis More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Channels Journal website
Volume:
9
Issue:
1
Pages:
44-49
Publication date:
2014-10-24
DOI:
EISSN:
1933-6969
ISSN:
1933-6969
Source identifiers:
492139
Language:
English
Keywords:
Pubs id:
pubs:492139
UUID:
uuid:39b00288-a5fc-41a2-8187-7952a0c43fc1
Local pid:
pubs:492139
Deposit date:
2014-12-05

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