Journal article icon

Journal article

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

Abstract:

Several recent ion channel structures have revealed large side portals, or ‘fenestrations’ at the interface between their transmembrane helices that potentially expose the ion conduction pathway to the lipid core of the bilayer. In a recent study we demonstrated that functional activity of the TWIK-1 K2P channel is influenced by the presence of hydrophobic residues deep within the inner pore. These residues are located near the fenestrations in the TWIK-1 structure and promote dewetting of th...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.4161/19336950.2014.981987

Authors


More by this author
Institution:
University of Oxford
Department:
MPLS, Department of Physics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
OXION Initiative in Ion Channels and Disease
Department:
MSD, Department of Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
OXION Initiative in Ion Channels and Disease
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Abd-Wahab, Firdaus
Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Pfizer Neusentis More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Channels Journal website
Volume:
9
Issue:
1
Pages:
44-49
Publication date:
2014-10-24
DOI:
EISSN:
1933-6969
ISSN:
1933-6969
URN:
uuid:39b00288-a5fc-41a2-8187-7952a0c43fc1
Source identifiers:
492139
Local pid:
pubs:492139

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP