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Journal article

Closed-loop all-optical interrogation of neural circuits in vivo

Abstract:
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41592-018-0183-z

Authors


Russell, LE More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0001-5884-794X
Hausser, M More by this author
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Funding agency for:
Packer, AM
Publisher:
Nature Research Publisher's website
Journal:
Nature Methods Journal website
Publication date:
2018-11-12
Acceptance date:
2018-09-04
DOI:
ISSN:
1548-7091
Pubs id:
pubs:941246
URN:
uri:39919898-5243-44ca-b764-6f657db3a0eb
UUID:
uuid:39919898-5243-44ca-b764-6f657db3a0eb
Local pid:
pubs:941246

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