- Abstract:
- Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1038/s41592-018-0183-z
-
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- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Methods Journal website
- Publication date:
- 2018-11-12
- Acceptance date:
- 2018-09-04
- DOI:
- ISSN:
-
1548-7091
- Pubs id:
-
pubs:941246
- URN:
-
uri:39919898-5243-44ca-b764-6f657db3a0eb
- UUID:
-
uuid:39919898-5243-44ca-b764-6f657db3a0eb
- Local pid:
- pubs:941246
- Keywords:
- Copyright holder:
- Zhang et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2018
Journal article
Closed-loop all-optical interrogation of neural circuits in vivo
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