Journal article

Does levodopa accelerate the pathologic process in Parkinson disease brain?

Abstract:: Background: Several in vitro studies have suggested levodopa (L-dopa) to be toxic to dopaminergic neurons and that it can modulate the aggregation process of α-synuclein. We investigated the relationship between cumulative lifetime dose of L-dopa and nigral neuronal count and Lewy body (LB) pathology in Parkinson disease (PD).

Methods: Density of pigmented neurons was measured unilaterally in a single section of substantia nigra (SN) with delineation of the dorsal and ventral tiers ...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Parkkinen, L., O'Sullivan, S., Kuoppamaki, M., Collins, C., Kallis, C., Holton, J., Williams, D., Revesz, T., & Lees, A. (2011). Does levodopa accelerate the pathologic process in Parkinson disease brain? Neurology, 77(15), 1420–1426.

MLA Style

Parkkinen, L., et al. “Does Levodopa Accelerate the Pathologic Process in Parkinson Disease Brain?” Neurology, vol. 77, no. 15, American Academy of Neurology, 2011, pp. 1420–26.

Chicago Style

Parkkinen, L, S O'Sullivan, M Kuoppamaki, C Collins, C Kallis, J Holton, D Williams, T Revesz, and A Lees. 2011. “Does Levodopa Accelerate the Pathologic Process in Parkinson Disease Brain?” Neurology 77 (15): 1420–26.
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Files:: Parkkinen et al. 2011 Neurology_Levodopa.pdf

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Publisher copy:: 10.1212/WNL.0b013e318232ab4c

Authors

+ Parkkinen, L More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Clinical Neurosciences

Role:

Author

+ O'Sullivan, S More by this author

Role:

Author

+ Kuoppamaki, M More by this author

Role:

Author

+ Collins, C More by this author

Role:

Author

+ Kallis, C More by this author

Role:

Author

More authors...

Funding

+ Orion Corporation More from this funder

Funding agency for:

Parkkinen, L

Bibliographic Details

Publisher:: American Academy of Neurology
Journal:: Neurology More from this journal
Volume:: 77
Issue:: 15
Pages:: 1420-1426
Publication date:: 2011-09-01
DOI:: 10.1212/WNL.0b013e318232ab4c
EISSN:: 1526-632X
ISSN:: 0028-3878

Item Description

Pubs id:: pubs:579200
UUID:: uuid:39857240-2b7a-45ea-ad3c-b8455621abec
Local pid:: pubs:579200
Source identifiers:: 579200
Deposit date:: 2015-12-09

Terms of use

Copyright holder:: AAN Enterprises, Inc
Copyright date:: 2011
Notes:: Copyright © 2011 by AAN Enterprises, Inc. All rights reserved.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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