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Does levodopa accelerate the pathologic process in Parkinson disease brain?

Abstract:

Background: Several in vitro studies have suggested levodopa (L-dopa) to be toxic to dopaminergic neurons and that it can modulate the aggregation process of α-synuclein. We investigated the relationship between cumulative lifetime dose of L-dopa and nigral neuronal count and Lewy body (LB) pathology in Parkinson disease (PD).

Methods: Density of pigmented neurons was measured unilaterally in a single section of substantia nigra (SN) with delineation of the dorsal and ventral tiers ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1212/WNL.0b013e318232ab4c

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
O'Sullivan, SS More by this author
Kuoppamaki, M More by this author
Collins, C More by this author
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Funding agency for:
Parkkinen, L
Publisher:
American Academy of Neurology Publisher's website
Journal:
Neurology Journal website
Volume:
77
Issue:
15
Pages:
1420-1426
Publication date:
2011-09-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:39857240-2b7a-45ea-ad3c-b8455621abec
Source identifiers:
579200
Local pid:
pubs:579200

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